Hypochromic microcytic anaemias and thalassemia

How to tell apart iron-deficiency anemia and thalassemia May 10, Q. I am having trouble differentiating between mild thalassemia and iron-deficiency anemia. I am not sure why the red cell distribution width would be lower in thalassemia than IDA.

Hypochromic microcytic anaemias and thalassemia

The genetic results of the patients showed that 28 patients Seven patients with alpha triplication were not grouped phenotypically. Turkey also has a high alpha-thalassemia frequency because of its geographic position. The first screening study of alpha-thalassemia by sensitive DNA method gene mapping was published in [ 12 ].

The frequency of alpha-thalassemia was detected at 3. Arcasoy reported that the frequency of alpha-thalassemia in Turkey was 0. The diagnosis of alpha-thalassemia is also important in patients with unsolved hypochromic microcytic anemia.

We found a rate of alpha-thalassemia as high as The types of alpha-thalassemia mutations are variable depending on geographic region. The most common mutations were the 3. According to the study by Guvenc et al.

Hypochromic anemia - Wikipedia

They also performed the largest study in Turkey with premarital couples and anemic patients, excluding those with iron deficiency, and they detected alpha-thalassemia mutations in patients.

They demonstrated 11 different genotypes; the 3. Although they tested few patients and detected mutations in only 9 patients, their most common mutations were similar to those of other studies in Turkey. They tested individuals and detected mutations in 97 patients.

Their inclusion criteria for the study were similar to ours.

Hypochromic microcytic anaemias and thalassemia

They reported that 3. In addition, they reported FIL double-gene deletion for the first time in in Turkey. In their study, deletion mutations were detected in These findings are similar to those of other studies addressing alpha-thalassemia in the world.

There are also published studies from Turkey about HbH disease [ 20212223 ]. In that study, 20 patients with HbH had 3 alpha-gene deletions, while the remaining 12 cases were caused by the combination of alpha-gene deletion and point mutation.

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We found a very heterogeneous distribution of alpha-thalassemia mutations. We present the results of our study and other studies from Turkey in Table 3 [ 17181920212425 ].

Hypochromic microcytic anaemias and thalassemia

In our study, we found 3 mutations that not been reported previously in Turkey. One-third of the mutations from the strip assay kit were not determined, similar to other studies from different parts of Turkey.Jan 12,  · Thalassemia is a microcytic-hypochromic anemia. Its cause is a decreased synthesis of one or several globin chains.

Its cause is a decreased synthesis of one or several globin chains. Since globin synthesis is flawed, the disease is one of the so-called hemoglobinopathies/5(3). Microcytic hypochromic anemia is a common form of anemia in children that is caused by defects in the synthesis of globin, heme or in the acquisition and distribution of iron.

Microcytic anaemia is any of several types of anaemia characterized by small red blood cells (called microcytes).The normal mean corpuscular volume (abbreviated to MCV on full blood count results) is fL, with smaller cells (microcytic and larger cells (> fL) as macrocytic (the latter occur in macrocytic anemia).The ICD D The most common causes of microcytosis are iron deficiency anemia and thalassemia trait.

Other diagnoses to consider include anemia of chronic disease, lead toxicity, and sideroblastic anemia. Hypochromic anemia, or Hypochromic anaemia, is a generic term for any type of anemia in which the red blood cells (erythrocytes) are paler than normal.

(Hypo - refers to less, and chromic means color.). Microcytic Anemia and Thalassemia. hematology 1 chapter 5.

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STUDY. PLAY. anemia. RBCs are no longer able to supply oxygen to the body tissues. microcytic. small RBCs Clinical conditions for Microcytic - Hypochromic Anemia (5) Iron deficiency anemia Thalassemia Sideroblastic anemia infection inflammation.

Blood disease - Hypochromic microcytic anemias | benjaminpohle.com